About the American Journal of Physiology-Renal Physiology
The American Journal of Physiology-Renal Physiology publishes original manuscripts on timely topics in both basic science and clinical research. Published articles address a broad range of subjects relating to the kidney and urinary tract, and may involve human or animal models, individual cell types, and isolated membrane systems. Also covered are the pathophysiological basis of renal disease processes, regulation of body fluids, and clinical research that provides mechanistic insights. Studies of renal function may be conducted using a wide range of approaches, such as biochemistry, immunology, genetics, mathematical modeling, molecular biology, as well as physiological and clinical methodologies.
Article Types
Rapid Reports
Rapid Reports are short papers presenting important new findings that could potentially have a major impact on the field. The manuscript does not need to tell a complete story but must be compelling, innovative, and novel. The manuscript should not exceed 4,000 words, including references and figure legends, and 4 figures and/or tables. Rapid Reports will be peer reviewed within 10 days. If requested, authors will be asked to submit a revision 14 days after the first decision. A final decision on first revisions will be made within 5 days of resubmission. Authors will be encouraged to fully comply with reviewer comments and submit only one revision. All Rapid Reports accepted for publication will be highlighted in the online journal as "featured papers" and have the option for a podcast at the author's and editors' discretion. Note: Only video files are permitted as supplemental data for Rapid Reports. Other types of supplemental files (e.g., figures, tables, appendixes, data sets) are not permitted.
Research Articles
Research articles present important new research results including the entire contents of a research project. Research articles include an abstract, an introduction, methods and results sections, a discussion, and relevant citations. Inclusion of links to data supplements and source data are permitted; see policy. Articles are peer-reviewed.
Perspectives
This category of article serves as a forum in which to disseminate new and original lines of thinking in physiology. These short articles go beyond the scope of invited reviews and should present original ideas that can be derived from our current knowledge base. Some Perspectives articles may challenge current dogma and will be considered for publication based on the scientific merit of the argument presented. These Perspective articles will be subject to peer review. Some articles will be invited, but unsolicited articles are welcome. Perspectives must be authored by experts in the field under discussion, such expertise having been demonstrated by original research published by the author(s) in peer-reviewed journals indexed in the major services, such as PubMed. Perspectives should not include original, unpublished data. In all cases, determining whether a proposed Perspective is within scope and acceptable for publication is a matter committed to the discretion of the editors. These articles should be about 1,500 words long, excluding references, and may include two figures.
Innovative Methodology
Research in physiology depends crucially on the development of new methods of data collection and analysis. Manuscripts submitted under this category should describe new methods for the recording, collection, and/or analysis of data relevant to understanding how the physiological system works. Manuscripts will be reviewed taking into consideration the following criteria:
The novelty of the new method. Papers should not be minor incremental improvements of old methods, but have a real new component.
The manuscript must describe the method in sufficient detail to enable others to implement or replicate the method or procedure.
The manuscript should carefully describe the advantages and disadvantages of the new method, with its limitations and strengths laid out clearly for the reader.
The manuscript must illustrate the use of the method to demonstrate that it actually works. It is not necessary to use the method in an extensive study of a biological problem, but a "proof of principle" demonstration is required. Where possible, the method should be applied to real physiological data.
Manuscripts should be of the length required to meet these criteria. Extensive technical details, mathematical derivations, etc. can be placed into an Appendix if they will interrupt the flow of the manuscript but may be additionally helpful to others wishing to implement the technique.
Review Articles
Review articles provide synthesis of state-of-the-art knowledge in a defined area highlighting new questions and pointing to future research directions. They encompass examination of biological processes, systems, and models, and technologies for their study. The primary purpose is to educate readers by providing a comprehensive view of completed works presented in a concise, unified format; however, appropriate inclusion of unpublished data is permissible. Utilization of figures is encouraged. Typically, reviews are invited and all are peer-reviewed. Review articles must be authored by experts in the field under discussion, such expertise having been demonstrated by original research published by the author(s) in peer-reviewed journals indexed in the major services, such as PubMed.
Typically, reviews are invited and all are peer-reviewed. Authors should email a pre-submission inquiry—including a working title, author and affiliation lists, abstract, and brief outline of the content—to the editorial office for approval by the editors.
Please note that prior to review, all review articles will be examined for originality using CrossCheck screening software to compare the submitted text to all available literature, including previous publications from the same author(s).
Editorials
Editorials provide commentary by the Editor, Associate Editors, and other scientists and experts on issues related to the Journal's mission as well as of general interest to our readers. Unsolicited editorials will be considered for publication. Acceptance will reside with the editors. Editorials must be authored by experts in the field under discussion, such expertise having been demonstrated by original research published by the author(s) in peer-reviewed journals indexed in the major services, such as PubMed.
Letters to the Editor
In all cases, determining whether a proposed Letter to the Editor is acceptable for publication is a matter committed to the discretion of the editors. Letters, including an informative title, should be short, approximately one journal column (500 words). Letters are reviewed by the appropriate editor and are subject to editing and possible abridgment. Letters to the Editor must be authored by experts in the field under discussion, such expertise having been demonstrated by original research published by the author(s) in peer-reviewed journals indexed in the major services, such as PubMed. Letters to the Editor should not include original, unpublished data. If a proposed Letter is found acceptable, a copy will be sent to the author of the original article if applicable; that author will have an opportunity to provide a rebuttal with new material that will be considered for publication with the Letter. Letters to the Editor may also simply address matters of general interest to the readership.
Physiology in Medicine
Manuscripts submitted for the Physiology in Medicine series should discuss a relatively narrow aspect of basic physiology as it relates to the pathophysiology or treatment of a specific disease (or group of diseases). The disease in question should be one that the specialist in internal medicine commonly encounters in his/her practice. By emphasizing a strong connection between laboratory research and clinical medicine, we hope to stimulate interest in translational research among clinicians and to encourage medical students and young physicians to follow a scientific pathway in their careers. However, authors should be aware that the PIM articles will be designed to appeal primarily to clinicians who may not be specifically trained in current laboratory methods so that descriptions of laboratory methods and physiologic processes must be accessible to an intelligent, medically trained non expert.
The main point of the article should be to describe how important scientific discoveries or principles have affected our understanding of a disease, with implications for diagnosis or treatment. We intend for these articles to be highly focused, usually making only a few teaching points, but doing so in a way that makes the knowledge stick in the readers' memory. In addition to describing important aspects of laboratory research that have elucidated physiologic mechanisms, the manuscripts should also detail the ways in which this knowledge has had an impact on our understanding of the way diseases develop, are diagnosed, or treated in everyday practice.
Manuscripts for this series must be evidence based (with appropriate citations) rather than being based on expert opinion, although an expert interpretation of diverging points of view are often illuminating. We encourage the use of glossaries for explanation of terms that might be unfamiliar to the clinician. Liberal use of figures (if scientifically necessary in color) is also encouraged. We think that manuscripts in this series are often enhanced by collaboration between a bench researcher and a clinician and for this reason, we encourage joint authorship. Manuscript length should not exceed 2500 words plus tables and figures, with no more than 70 references. Graphics should be used liberally and should avoid excessive complexity. Because the articles are meant to be informative and to engage the clinician, they should be focused but not definitive, archival reviews. Each manuscript should conclude with a paragraph that summarizes the importance of the discussion for the clinician in easily understandable language.
References should be listed and cited in the style of the journals of the American Physiological Society. Authors should refer to the Instructions for Authors appropriate for the specific APS journal to which the PIM article will be submitted.
Categories
Various article types can be published under the following Categories, or headings:
Calls for Papers
Calls for Papers will have headings that change depending on the topic. Manuscripts of any type may be submitted in response to an announced Call for Papers. These manuscripts are peer reviewed, and are published together under the topic heading.
Special Sections
Manuscripts of any type may be submitted to one of these Special Sections.
Historical Articles
Manuscripts on the history of physiology may be submitted to the Editor.
Cores of Reproducibility in Physiology (CORP) - Invited article
Experts will be invited to write a detailed, instructional paper, either a research article or review article, that represents best practice in physiology for a particular method or equipment that is in broad, common use. This series of articles is available across all APS journals and is developed in response to the challenge to improve transparency and reproducibility in published research results. To build on the value of the collective best practices the title of the paper should start with "Cores of Reproducibility in Physiology: ............." where the specific device or method would appear after the semicolon. The following key elements, must be included:
A description of the method/device and its purported use(s)
Details regarding proper use, including calibration, validation, range, sensitivity, specificity, reproducibility (addressing variance of the method itself, within-subject variance and between-subject variance)
Particular details of practical importance that may not be widely appreciated - especially where things can go wrong.
A critical discussion of what the method/device can do if used properly
A critical discussion of limitations of the method/device (what it cannot do or is not intended to do)
These invited articles will be peer reviewed with standard rigor and in light of meeting the above-listed criteria.
Systematic Review
A systematic review answers a defined research question by collecting and summarizing all empirical evidence that fits pre-defined criteria. Systematic reviews include an explicit set of objectives, a search to identify all literature that fits the objectives, an assessment of the validity of the information in the collected literature, and a synthesis of the findings of this literature. Unlike traditional literature reviews that can be biased by incomplete searches of the literature and subjective interpretation of the findings, systematic reviews must include a detailed and comprehensive plan to identify, appraise and synthesize all relevant information on a topic. Systematic Reviews are invited and all are peer-reviewed.
Preferred Reporting Items for Systematic Reviews and Meta-Analyses is the defining standard for composing a systematic review (Moher et al. 2009). Systematic Reviews must adhere to the PRISMA statement and the PRISMA checklist, which is available at: http://www.prisma-statement.org
Often, but not always, systematic reviews include a meta-analysis, or statistical evaluation of the relevant information in the literature on a topic.
Systematic reviews published in APS journals must adhere to the following criteria:
The title of the article must indicate that it is a systematic review or meta-analysis of the literature (e.g., An Analysis of Vitamin-D Supplements on Bone Density: A Systematic Review).
The article must explicitly state adherence to the PRISMA standard and PRISMA checklist (http://www.prisma-statement.org)
Registration of the systematic review in a database such as PROSPERO (https://www.crd.york.ac.uk/PROSPERO/), if applicable, must be indicated in the article.
The search strategy must be explicitly indicated, including databases, years considered, and search terms.
The criteria for inclusion and exclusion of articles obtained during the search must be provided.
The characteristics of information extracted from articles must be specified.
If a meta-analysis is included, the methodology for extracting data from articles and combining results must be defined, as well as confidence intervals and measures of consistency.
Risk of bias across studies and limitations of the literature search and analysis must be stated.
Moher D, Liberati A, Tetzlaff J, Altman DG, and Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6: e1000097, 2009.
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