帝国理工学院生物工程系招收博士研究生

帝国理工学院生物工程系招收博士研究生     

About the Project

PhD studentship in the Department of Bioengineering at Imperial College London

Overview

This is an experimental fluid mechanics project, focussed on investigating the flow of blood in the microvasculature. Experiments will include use of use micro-particle image velocimetry, human blood samples and microfabricated models to investigate how changes to red blood cells affect the flow.

Project Motivation

Microcirculatory dysfunction is present in a range of diseases such as diabetes, malaria and sickle cell anaemia. There is an intimate connection between the flow of blood and the function of the microvasculature, but understanding of blood flow in small vessels is still limited.

The fluid mechanics of blood flow in microvessels are largely determined by the behaviour of the red blood cells (RBCs). Their considerable deformability and propensity to reversibly aggregate result in complex flows, particularly in branching microvascular networks. Changes to RBC properties occur in microvascular diseases, and it is our hypothesis that this may play a causal role in the health consequences of these diseases.

To investigate this hypothesis, we must first better understand microvascular blood flow, and to do this, we need experimental measurements.

The successful candidate will have a passion for fluid dynamics and experimental research and be happy to work independently and as part of a highly collaborative team. During the project, the candidate will develop a wide range of technical skills including µPIV, rheometry, image processing, microfabrication, microscopy, MATLAB and LabVIEW. Prior experience in these fields is beneficial but not required.

Please send enquiries and/or your application to Dr van Batenburg-Sherwood via email (jvbsherwood@imperial.ac.uk)

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