Post-doctoral Fellow, Brigham and Women’s Hospital, Harvard Medical School, Boston
The Functional Genomics Laboratory at Brigham and Women’s Hospital, Harvard Medical School is looking for exceptional postdoctoral fellowship candidates to join us to investigate the function of genes identified by genome-wide association studies (GWAS) in respiratory diseases, including asthma, Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF).
Our research group has pioneered comprehensive functional characterization on genomic regions associated with pulmonary diseases.We have identified novel regulation of cellular metabolism pathway, innate immune response, epithelial repair/regeneration by GWAS genes implicated in lung diseases. Fellows will closely work with an interdisciplinary team, consisting of geneticists, cell biologists and molecular biologists. The fellow will work on one of several NIH-funded projects including CRISPRi screening for functional variants, in depth mechanistic studies on COPD/IPF GWAS genes modulating alveolar epithelial regeneration and cellular metabolism as well as on the integration of epigenetics and chromatin interaction to infer GWAS causal genes. The candidate will work directly with Dr. Anny Xiaobo Zhou, the Director of the Functional Genomics Laboratory at the Brigham and Women’s Hospital.
Our inter-disciplinary research efforts will combine cellular models and ex vivo lung organoid models with in vivo disease-relevant mouse models to pinpoint novel biology of lung diseases. We are interested in how these novel GWAS genes participate in lung epithelial injury/repair process, modulate lipid and glucose metabolism and determine innate immune response in epithelial progenitors intrinsically and through cell-cell communications with mesenchymal and immune niche cells. We are interested in dissecting the genetic determinants that modulate the immunologic and metabolic cues for lung epithelial progenitor repair/regeneration. Identification of tunable pathways regulated by these novel GWAS genes may facilitate novel drug development and/or repurpose of preexisting drugs to treat patients with pulmonary conditions.
Postdoctoral candidates with solid knowledge and strong skills related to CRISPR editing, epithelial biology, organoid models, cellular metabolism or immune response as well as strong motivation to work in a dynamic and challenging research area are strongly encouraged to apply. Please submit inquires and applications including CV, the names of three references, and a cover letter to Dr. Zhou, Associate Professor in Medicine, Director of the Functional Genomics Laboratory: rexiz@channing.harvard.edu. See more information in https://gwas2bio.bwh.harvard.edu.
Brigham and Women’s Hospital (BWH) is a Harvard Medical School affiliated institution, with over 1000 principal investigators.The Channing Division of Network Medicine is a research division within the Department of Medicine whose goal is to define the etiology and reclassify complex disease using network-, function- and systems-based approaches. BWH is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
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